Phytochemicals, Biodegradation, Cytocompatibility and Wound Healing Profiles of Chitosan Film Embedded Green Synthesized Antibacterial ZnO/CuO Nanocomposite
نویسندگان
چکیده
Open wound ulcer treatment remains a great challenge in care management especially involving multi drug resistant (MDR) pathogen. Currently, lack of effectiveness commercially available dressing material is one the primary factors delaying healing. Therefore, transformation plain Chitosan (Cs) to antibacterial polymer nanocomposite with embedment Quercetin-ZnO/CuO biocide through green synthesis approach shed light for an efficient healing management. The present work studied phytochemicals, biodegradation, storage, cytocompatibility and profiles Cs film embedded from Calotropis gigantea (C. gigantea). HPLC was used detect Quercetin bioactive constituent. Our study demonstrated ZnO/CuO-Cs-1wt.% displayed highest cell viability (168.52 ± 14.46%) at 72 h treatment. Besides, fully biodegradable. also exhibited significantly enhanced migration (26.81 μm/h) closure (62.35 9.46%) 12 h. This finding supported by our vivo excisional open studies Sprague-Dawley (SD) rats, which showed progressive recovery 14 days. controllable release multiple metal ions ZnO/CuO-Cs might contribute recovery. highlighted promising outcomes
منابع مشابه
Antibacterial Activity and Wound Healing Effect of Nitric Oxide (NO)-Releasing Chitosan Film
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ژورنال
عنوان ژورنال: Journal of Polymers and The Environment
سال: 2023
ISSN: ['1566-2543', '1572-8919']
DOI: https://doi.org/10.1007/s10924-023-02902-1